Journal article
Development of a Core outcome set for fetal Myelomeningocele (COSMiC): Study protocol
S Altoukhi, CL Whitehead, G Ryan, J Deprest, L Joyeux, K Gallagher, J Drake, P Church, D Horn, Y Diambomba, JCA Carvalho, T Van Mieghem
Trials | BMC | Published : 2020
Abstract
Background: Open spina bifida (OSB) is one of the most common congenital central nervous system defects and leads to long-term physical and cognitive disabilities. Open fetal surgery for OSB improves neurological outcomes and reduces the need for ventriculoperitoneal shunting, compared to postnatal surgery, but is associated with a significant risk of prematurity and maternal morbidity. Fetoscopic surgery comes with less maternal morbidity, yet the question remains whether the procedure is neuroprotective and reduces prematurity. Comparison of outcomes between different treatment options is challenging due to inconsistent outcome reporting. We aim to develop and disseminate a core outcome se..
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Awarded by Engineering and Physical Sciences Research Council
Funding Acknowledgements
CLW is supported by a National Health and Medical Research Council of Australia Fellowship (#1142380). LJ is supported by a British (Innovative Engineering for Health award by the Wellcome Trust [WT101957] and Engineering and Physical Sciences Research Council [EPSRC; NS/A000027/1]) and a Belgian FWO TBM (Flemish applied biomedical research; T002618N) grants. JD is supported by the Great Ormond Street Hospital Charity fund. TVM is the recipient of a junior faculty award from the Department Of Obstetrics and Gynaecology at the University of Toronto. JDP is supported by the Great Ormond Street Hospital for Children Charity Fund. The views expressed are of the authors and not those of the funding bodies which had no role in the design or conduct of the study.